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  • Anti-PA28A / PSME1 antibody

Anti-PA28A / PSME1 antibody

Cat.#: 106703

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Product Information

  • Product Name
    Anti-PA28A / PSME1 antibody
  • Documents
  • Description
    Rabbit polyclonal to PA28A / PSME1
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human PA28A / PSME1
  • Alternative names
    proteasome (prosome antibody; macropain) activator subunit 1 (PA28 alpha) antibody; PSME1 antibody; IFI5111 antibody; PA28A antibody; PA28alpha antibody; REGalpha antibody; 11S regulator complex alpha subunit antibody; 11S regulator complex subunit alpha antibody; 29-kD MCP activator subunit antibody; IGUP I-5111 antibody; REG-alpha antibody; activator of multicatalytic protease subunit 1 antibody; interferon gamma up-regulated I-5111 protein antibody; interferon-gamma IEF SSP 5111 antibody; interferon-gamma-inducible protein 5111 antibody; proteasome activator 28 subunit alpha antibody; proteasome activator complex subunit 1 antibody; proteasome activator subunit-1 antibody; proteasome (prosome antibody; macropain) 28 subunit antibody; alpha antibody; Psme1 antibody; AW413925 antibody; PA28a antibody; 11S regulator complex subunit alpha antibody; PA28 alpha subunit antibody; PA28alpha antibody; REG-alpha antibody; activator of multicatalytic protease subunit 1 antibody; protease (prosome antibody; macropain) 28 subunit antibody; alpha antibody; proteasome activator 28 subunit alpha antibody; proteasome activator complex subunit 1 antibody; PA28A antibody; IFI5111 antibody; REGalpha antibody; PA28alpha antibody; PA28a antibody; AW413925 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human PA28A / PSME1 (rh PA28A / PSME1; Q06323; Met1-Tyr249). PA28A / PSME1 specific IgG was purified by Human PA28A / PSME1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 2-10 μg/ml

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human PA28A / PSME1. The detection limit for Human PA28A / PSME1 is < 0.039 ng/well.

  • Validations

    PA28A / PSME1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    PA28A / PSME1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME1 gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring.
  • References
    • Honore B. et al., 1994, Eur J Biochem 218 (2): 421-30.
    • Wilkinson. et al., 2003, J. Biochem. (Germany) 270 (11): 2459-66.
    • Rual Jean-François. et al., 2005, Nature. (England) 437 (7062): 1173-8.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"