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  • Anti-Oncostatin M/OSM antibody

Anti-Oncostatin M/OSM antibody

Cat.#: 105789

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Product Information

  • Product Name
    Anti-Oncostatin M/OSM antibody
  • Documents
  • Description
    Rabbit polyclonal to Oncostatin M/OSM
  • Tested applications
    ELISA, WB
  • Species reactivity
    Mouse Oncostatin M / OSM
  • Alternative names
    OncoM antibody; MGC20461 antibody; OncoM antibody; Oncostatin M antibody; Oncostatin M antibody; OSM antibody; Osm antibody; RP23-453B22.1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse Oncostatin M / OSM (rh Oncostatin M / OSM; P53347; Met1-Arg206). Oncostatin M / OSM specific IgG was purified by Mouse Oncostatin M / OSM affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 10-20 μg/ml

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse Oncostatin M / OSM. The detection limit for Mouse Oncostatin M / OSM is 0.00975 ng/well.

  • Validations

    Oncostatin M / OSM Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    Oncostatin M / OSM Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-teminal most 31 amino acids produces the fully active 196 residue form.
  • References
    • Tanaka M, et al. (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 149: 39-52.
    • Auguste P, et al. (1997) Signaling of type II oncostatin M receptor. J Biol Chem. 272 (25): 15760-4.
    • Zarling JM, et al. (1986). Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci. 83 (24): 9739-43.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"