Anti-Nesprin3 Rabbit antibody
Nesprin3 Rabbit monoclonal antibody
KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341 antibody
Antigen: Recombinant protein of human Nesprin3
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of Nesprin3 in Jurkat,Hela cell lysates using Nesprin3 Rabbit mAb(1:1000 diluted).Predicted band size:112kDa.Observed band size:112kDa.
Swiss-Prot Acc.Q6ZMZ3.As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
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