Rabbit Polyclonal to Human MMP12
IHC-P, ICC/IF, IF
Human MMP-12 / MMP12
HME antibody; ME antibody; MGC138506 antibody; MME antibody; MME antibody; Mmel antibody; MMP12 antibody; Mmp12 antibody; MMP-12 antibody; MMP-12 antibody; ME antibody; HME antibody; MME antibody; MMP-12 antibody; Mmel antibody; AV378681 antibody; AV378681 antibody
Produced in rabbits immunized with purified, recombinant Human MMP-12 / MMP12 . MMP-12 / MMP12 specific IgG was purified by Human MMP-12 / MMP12 affinity chromatography.
0.2 μm filtered solution in PBS
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
IHC-P: 0.1-2 μg/mL
ICC/IF: 0.5-3 μg/mL
MMP-12 / MMP12 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
MMP-12 / MMP12 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunofluorescence
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. Macrophage metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, MMP12, and MMP-12, is a secreted protein which belongs to the peptidase M10A family. MMP12 is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be involved in tissue injury and remodeling and has significant elastolytic activity. It may be related to prognosis in breast cancer patients. MMP12 promotes fibrosis by limiting the expression of specific ECM-degrading MMPs. Like MMP12, MMP13 expression is highly dependent on IL-13 and type I I-IL-4 receptor signaling. MMP12 is a potent proinflammatory and oncogenic molecule. MMP12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.
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