Anti-MAGOH antibody

Anti-MAGOH antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to MAGOH

ELISA, WB, IP

Human MAGOH

MAGOH1 antibody; MAGOHA antibody; Mos2 antibody; Mago-m antibody; mago-nashi homolog antibody; proliferation-associated (Drosophila) antibody; MAGOH antibody; RP5-1024G6.4 antibody; MAGOH1 antibody; MAGOHA antibody; protein mago nashi homolog antibody; mago-nashi homolog antibody; proliferation-associated (Drosophila) antibody; Magoh antibody; RP23-40G2.2 antibody; Mago-m antibody; Mos2 antibody; protein mago nashi homolog antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human MAGOH (rh MAGOH; NP_002361.1; Met1-Ile146). MAGOH specific IgG was purified by Human MAGOH affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.