Anti-Lyn (1C8) Mouse antibody

Anti-Lyn (1C8) Mouse antibody

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Lyn (1C8) Mouse monoclonal antibody

WB

Human

AA407514 ;EC 2.7.10.2 ;FLJ26625 ;Hck 2 ;JTK 8 ;JTK8 ;Lck/Yes related novel protein tyrosine kinase ;LYN ;LYN proto oncogene antibody; Src family tyrosine kinase ;LYN_HUMAN ;ONCOGENE LYN ;p53Lyn ;p56Lyn ;Tyrosine protein kinase LYN ;Tyrosine-protein kinase Lyn ;V yes 1 Yamaguchi sarcoma viral related oncogene homolog ;Yamaguchi sarcoma viral (v yes 1) related oncogene homolog. antibody

IgG1

Antigen: Purified recombinant human Lyn protein fragments expressed in E.coli.

Monoclonal

PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P07948.Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.