Anti-Kappa Opioid Receptor Rabbit antibody

Anti-Kappa Opioid Receptor Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Kappa Opioid Receptor Rabbit monoclonal antibody

WB, IHC-P, IP

Mouse, Rat

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1 antibody

Rabbit IgG

Antigen: A synthetic peptide of mouse Kappa Opioid Receptor

Monoclonal

Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P33534.G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.