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  • Anti-JAG1/Jagged 1(CD339) antibody

Anti-JAG1/Jagged 1(CD339) antibody

Cat.#: 101045

Special Price 161.3 USD

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Product Information

  • Product Name
    Anti-JAG1/Jagged 1(CD339) antibody
  • Documents
  • Description
    Mouse monoclonal to JAG1/Jagged 1(CD339)
  • Tested applications
  • Species reactivity
    Human JAG1 / Jagged 1
  • Immunogen
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAG1 / Jagged 1 (rh JAG1 / Jagged 1; NP_000205.1; Met1-Ser1046) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
  • Clonality
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
  • Validations

    JAG1 / Jagged 1 Antibody (FITC), Mouse MAb, Flow cytometric

    JAG1 / Jagged 1 Antibody (FITC), Mouse MAb, Flow cytometric

    Profile of anti-JAG1(CD339) reactivity on HepG2 cells analyzed by flow cytometry.

  • Background
    Protein Jagged 1, also known as JAG1, JAGL1 and CD339, is a single-pass type I  membrane protein which contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expression of JAG1/Jagged 1 is up-regulated in cervical squamous cell carcinoma. JAG1/Jagged 1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1/Jagged 1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1/Jagged 1 may be involved in cell-fate decisions during hematopoiesis.  JAG1/Jagged 1 seems to be involved in early and late stages of mammalian cardiovascular development. It inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1/Jagged 1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1/Jagged 1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation.
  • References
    • Oda al., 1997, Nat. Genet. 16:235-242.
    • Krantz I.D. et al., 1998, Am. J. Hum. Genet. 62:1361-1369.
    • Li L. et al., 1998, Immunity. 8:43-55.
    • Jones E.A. et al., 2000, J. Med. Genet. 37: 658-662.
    • Roepke al., 2003, Hum. Mutat. 21:100-100.
    • Jurkiewicz al., 2005, Hum. Mutat. 25:321-321.
    • Warthen al., 2006, Hum. Mutat. 27:436-443.