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  • Anti-IL-1 alpha / IL-1F1 / IL1A antibody

Anti-IL-1 alpha / IL-1F1 / IL1A antibody

Cat.#: 103903

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-IL-1 alpha / IL-1F1 / IL1A antibody
  • Documents
  • Description
    Rabbit polyclonal to IL-1 alpha / IL-1F1 / IL1A
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Mouse IL-1 alpha / IL-1F1 / IL1A
  • Alternative names
    IL1 antibody; IL-1 alpha antibody; IL1A antibody; IL-1A antibody; IL1-ALPHA antibody; IL1F1 antibody; IL1 antibody; IL-1A antibody; IL1F1 antibody; IL1-ALPHA antibody; Il-1a antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse IL-1 alpha / IL-1F1 / IL1A (rM IL-1 alpha / IL-1F1 / IL1A; NP_034684.2; Ser 115-Ser 270). IL-1 alpha / IL-1F1 / IL1A specific IgG was purified by Mouse IL-1 alpha / IL-1F1 / IL1A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL-1 alpha / IL-1F1 / IL1A. The detection limit for Mouse IL-1 alpha / IL-1F1 / IL1A is approximately 0.00245 ng/well.

    IHC-P: 0.5-3 μg/mL

  • Validations

    IL-1 alpha / IL-1F1 / IL1A Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    IL-1 alpha / IL-1F1 / IL1A Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of mouse IL1A in mouse-brain with rabbit polyclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

  • Background
    IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.
  • References
    • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
    • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
    • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
    • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"