Anti-IDO1 antibody

Cat.#: 142124

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Product Information

  • Product Name
    Anti-IDO1 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human IDO1
  • Tested applications
    ELISA, ICC/IF, IF
  • Species reactivity
    Human IDO1 / Indoleamine 2,3-dioxygenase
  • Alternative names
    Indoleamine 2 antibody; 3‑dioxygenase antibody; IDO-1 antibody; Ido antibody; IDO antibody; Ido1 antibody; IDO1 antibody; Indo antibody; INDO antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human IDO1 / Indoleamine 2,3-dioxygenase . IDO1 / Indoleamine 2,3-dioxygenase specific IgG was purified by Human IDO1 / Indoleamine 2,3-dioxygenase affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human IDO1 / Indoleamine 2,3-dioxygenase.

    ICC/IF: 0.5-1.5 μg/mL

  • Validations

    Human IDO1/Indoleamine 2,3‑dioxygenase Immunofluorescence(IF) 14707

    Human IDO1/Indoleamine 2,3‑dioxygenase Immunofluorescence(IF) 14707

  • Background
    Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.

    Immune Checkpoint
    Immune Checkpoint Detection: ELISA Antibodies
    Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"