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  • Anti-Histone H3 antibody
  • Anti-Histone H3 antibody
  • Anti-Histone H3 antibody
  • Anti-Histone H3 antibody

Anti-Histone H3 antibody

Cat.#: 142227

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Special Price 129.0 USD

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Product Information

  • Product Name
    Anti-Histone H3 antibody
  • Documents
  • Description
    Mouse Monoclonal to Human Histone H3
  • Tested applications
    WB, IHC-P, IP
  • Species reactivity
    Human Histone H3
  • Isotype
    Mouse IgG2b
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the human Histone H3. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 1/1000-1/10000

    IHC-P: 1/50-1/1000

    IP: 4-10 uL/mg of lysate

  • Validations

    Histone H3 Antibody, Mouse MAb, Immunoprecipitation

    Histone H3 Antibody, Mouse MAb, Immunoprecipitation

    Histone H3 Antibody, Mouse Mab, Immunochemistry

    Histone H3 Antibody, Mouse Mab, Immunochemistry

    Histone H3 Antibody, Mouse Mab, Immunochemistry

    Histone H3 Antibody, Mouse Mab, Immunochemistry

    Histone H3 Antibody, Mouse MAb, Western blot

    Histone H3 Antibody, Mouse MAb, Western blot

  • Background
    Histone H3 is a histone protein. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. They play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. Histone H3 is characterized by a main globular domain and a long N-terminal tail. It is involved with the structure of the nucleosomes of the 'beads on a string' structure. There are five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histone H3 is the most extensively modified of the five histones. In the emerging field of epigenetics, it is thought that Histone H3 plays a key role, cause its sequence variants and variable modification states function in the dynamic and long term regulation of genes.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"