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Product Name
Anti-Hexokinase I (6B8) Mouse antibody
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Description
Hexokinase I (6B8) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
BB404130; Brain form hexokinase; dea; EC 2.7.1.1; Glycolytic enzyme; HEXOKIN; Hexokinase PI; Hexokinase type I; Hexokinase antibody; tumor isozyme; Hexokinase-1; Hexokinase-A; HK I; HK1; HK1 tb; Hk1-s; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; HXK1_HUMAN; mHk antibody
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Isotype
Mouse IgG1
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Preparation
Antigen: Purified recombinant human Hexokinase 1 protein fragments expressed in E.coli
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of Hexokinase 1 in MCF7,Jurkat,CHO-K1,C2C12,C6,3T3 and Hela cell lysates using Hexokinase 1 mouse mAb (1:1000 diluted). Predicted band size:102KDa. Observed band size:102KDa.
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Background
Swiss-Prot Acc.P19367.Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"