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Product Name
Anti-HDAC6 (3B2) Mouse antibody
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Description
HDAC6 (3B2) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Alternative names
FLJ16239 ;HD 6 ;HD6 ;HDAC 6 ;HDAC6 ;HDAC6_HUMAN ;Histone deacetylase 6 (HD6) ;Histone deacetylase 6 ;JM 21 ;JM21 ;KIAA0901 ;OTTHUMP00000032398 ;OTTHUMP00000197663 antibody
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Isotype
IgG2a
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Preparation
Antigen: Purified recombinant human HDAC6 protein expressed in E.coli.
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of HDAC6 in T47D,Jurkat CHO-K1(B) and CHO-K1 transfected by HDAC6-fragment EGFP fusion proteinuff08Auff09cell lysates using HDAC6 mouse mAb (1:1000 diluted).
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Background
Swiss-Prot Acc.Q9UBN7.Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"