Anti-HDAC3 (7G6) Mouse antibody

Cat.#: 168522

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Product Information

  • Product Name
    Anti-HDAC3 (7G6) Mouse antibody
  • Documents
  • Description
    HDAC3 (7G6) Mouse monoclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human
  • Isotype
    Mouse IgG2a
  • Preparation
    Antigen: Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Ascitic fluid containing 0.03% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    ICC: 1/200 - 1/1000

    ELISA: 1/10000

  • Validations

    Immunoprecipitation analysis of Hela cell lysates using HDAC3 mouse mAb.

    Immunoprecipitation analysis of Hela cell lysates using HDAC3 mouse mAb.

    Western blot detection of HDAC3 in COS7,C6,Hela and 3T3 cell lysates using HDAC3 mouse mAb (dilution 1:500).Predicted band size:48.8KDa.Observed band size:48.8KDa.

    Western blot detection of HDAC3 in COS7,C6,Hela and 3T3 cell lysates using HDAC3 mouse mAb (dilution 1:500).Predicted band size:48.8KDa.Observed band size:48.8KDa.

    Immunocytochemistry of HeLa cells using HDAC3 mouse mAb (dilution 1:100).

    Immunocytochemistry of HeLa cells using HDAC3 mouse mAb (dilution 1:100).

  • Background
    Swiss-Prot Acc.O15379.HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"