Anti-GOPC antibody

Anti-GOPC antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human GOPC

WB, ELISA, IHC-P, IP

Human GOPC / PIST

golgi-associated PDZ and coiled-coil motif containing antibody; GOPC antibody; CAL antibody; FIG antibody; GOPC1 antibody; PIST antibody; dJ94G16.2 antibody; CFTR-associated ligand antibody; Golgi associated PDZ and coiled-coil motif containing protein antibody; PDZ protein interacting specifically with TC10 antibody; PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 antibody; dJ94G16.2 PIST antibody; fused in glioblastoma antibody; golgi associated PDZ and coiled-coil motif containing antibody; Gopc antibody; 2210402P09Rik antibody; AI844555 antibody; CAL antibody; FIG antibody; GOPC1 antibody; PIST antibody; Golgi-associated PDZ and coiled-coil motif-containing protein antibody; PDZ domain-containing protein PIST antibody; PDZ protein interacting specifically with TC10 antibody; CAL antibody; Cal antibody; FIG antibody; PIST antibody; GOPC1 antibody; dJ94G16.2 antibody; FIG antibody; PIST antibody; GOPC1 antibody; AI844555 antibody; 2210402P09Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human GOPC / PIST . GOPC / PIST specific IgG was purified by Human GOPC / PIST affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

GOPC, also known as PIST, interacts specifically with TC10 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and in both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells. The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin binds to the PDZ domain of PIST. The co-localization of PIST and Rhotekin at the Golgi apparatus can be detected in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized cells. PIST and Rhotekin are recruited from the cytosol to AJs as the cell becomes polarized. Expression of constitutively active Rho or prevention of Rhotekin-PIST interaction induced diffuse cytoplasmic distribution of Rhotekin in polarized MDCK cells. GOPC may regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. It may also regulate the intracellular trafficking of the ADR1B receptor. GOPC is ubiquitously expressed and its overexpression results in CFTR intracellular retention and degradation in the lysosomes.