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Product Name
Anti-FGF10 antibody
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Description
Rabbit Polyclonal to Human FGF10
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Tested applications
WB, IHC-P, IP
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Species reactivity
Human FGF10 / KGF2
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Alternative names
AEY17 antibody; Fgf-10 antibody; BB213776 antibody; Gsfaey17 antibody; BB213776 antibody; Fgf10 antibody; FGF10 antibody; Fgf-10 antibody; keratinocyte growth factor 2 antibody; produced by fibroblasts of urinary bladder lamina propria antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human FGF10 / KGF2, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 1-5 μg/ml
IHC-P: 0.1-2 μg/mL
IP: 4-8 μl/mg of lysate
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Validations
FGF10 / KGF2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
FGF10 / KGF2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
FGF10 / KGF2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF10 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"