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  • Anti-FGF1 Rabbit antibody

Anti-FGF1 Rabbit antibody

Cat.#: 166932

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-FGF1 Rabbit antibody
  • Documents
  • Description
    FGF1 Rabbit polyclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human FGF1
  • Clonality
    Polyclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of FGF1 in C6 cell lysates using FGF1 Rabbit pAb(1:1000 diluted).Predicted band size:17kDa.Observed band size:17kDa.

    Western blot detection of FGF1 in C6 cell lysates using FGF1 Rabbit pAb(1:1000 diluted).Predicted band size:17kDa.Observed band size:17kDa.

  • Background
    Swiss-Prot Acc.P05230.Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"