Rabbit polyclonal to Ephrin-B2
Htk-L antibody; LERK5 antibody; Lerk5 antibody; LERK-5 antibody; MGC126226 antibody; MGC126227 antibody; MGC126228 antibody; NLERK-1 antibody; RP11-272L14.1 antibody; Epl5 antibody; ELF-2 antibody; Eplg5 antibody; Htk-L antibody; Lerk5 antibody; LERK-5 antibody; NLERK-1 antibody; HTKL antibody; EPLG5 antibody; Htk-L antibody; LERK5 antibody; Efnb2 antibody; EFNB2 antibody; ELF-2 antibody; ephrin-B2 antibody; Ephrin-B2 antibody; Epl5 antibody; EPLG5 antibody; Eplg5 antibody; HTKL antibody; Htk-L antibody
Produced in rabbits immunized with purified, recombinant Mouse Ephrin-B2 (rh Ephrin-B2; NP_034241.2; Met1-Ala232). Ephrin-B2 specific IgG was purified by Mouse Ephrin-B2 affinity chromatography.
0.2 μm filtered solution in PBS
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse Ephrin-B2. The detection limit for Mouse Ephrin-B2 is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
Ephrin-B2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
EphrinB2 also known as EFNB2 is a member of the ephrin family. EphrinB2 is involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. The transmembrane-associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall.
- Wang HU, et al. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93(5): 741-53.
- Gale NW, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230(2): 151-60.
- Shin D, et al. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 230(2): 139-50.
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