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Product Name
Anti-Epac1 Rabbit antibody
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Description
Epac1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Epac1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000
IHC: 1/20
ICC/IF: 1/20
IP: 1/20
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Validations
Western blot detection of Epac1 in 3T3 cell lysates using Epac1 Rabbit pAb(1:1000 diluted).Predicted band size:104kDa.Observed band size:104kDa.
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Background
Swiss-Prot Acc.O95398.Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"