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  • Anti-CD98/SLC3A2 antibody
  • Anti-CD98/SLC3A2 antibody

Anti-CD98/SLC3A2 antibody

Cat.#: 105212

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Product Information

  • Product Name
    Anti-CD98/SLC3A2 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD98/SLC3A2
  • Tested applications
    IHC-P
  • Species reactivity
    Human CD98 / SLC3A2
  • Alternative names
    4F2 antibody; CD98 antibody; MDU1 antibody; 4F2HC antibody; 4T2HC antibody; NACAE antibody; CD98HC antibody; 4F2 antibody; Cd98 antibody; Ly10 antibody; Mdu1 antibody; 4F2HC antibody; Ly-10 antibody; NACAE antibody; Ly-m10 antibody; Mgp-2hc antibody; AI314110 antibody; AI314110 antibody; MDU1 antibody; NACAE antibody; NACAE antibody; Slc3a2 antibody; SLC3A2 antibody; 4F2 antibody; 4F2 antibody; 4F2HC antibody; 4F2HC antibody; 4T2HC antibody; Cd98 antibody; CD98 antibody; CD98HC antibody; Ly10 antibody; Ly-10 antibody; Ly-m10 antibody; Mdu1 antibody; Mgp-2hc antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human CD98 / SLC3A2 (rh CD98 / SLC3A2; P08195-1; Arg206-Ala630).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 0.5-5 μg/mL

  • Validations

    CD98 / SLC3A2 Antibody, Rabbit MAb, Immunohistochemistry

    CD98 / SLC3A2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human SLC3A2 in human kidney with rabbit monoclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections).

    CD98 / SLC3A2 Antibody, Rabbit MAb, Immunohistochemistry

    CD98 / SLC3A2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human SLC3A2 in human placenta with rabbit monoclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
  • References
    • Torrents D. et al., 1998, J Biol Chem. 273: 32437-45.
    • Pfeiffer R. et al., 1999, EMBO J. 18: 49-57.
    • Broeer A. et al., 2000, Biochem J. 349: 787-95.
    • Yanagida O. et al., 2001, Biochim Biophys Acta. 1514: 291-302.
    • Broeer A. et al., 2001, Biochem J. 355: 725-31.
    • Fort J. et al., 2007, J Biol Chem. 282: 31444-52.
    • Mayya V. et al., 2009, Sci Signal. 2: RA46-RA46.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"