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Product Name
Anti-CD55 Rabbit antibody
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Description
CD55 Rabbit monoclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Alternative names
CR; TC; DAF; CROM; CHAPLE antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human CD55
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/2000-1/10000
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Validations
Western blot detection of CD55 in Hela cell lysates using CD55 Rabbit mAb(1:1000 diluted).Predicted band size:41kDa.Observed band size:78kDa.
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Background
Swiss-Prot Acc.P08174.This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"