Anti-CD44 antibody

Cat.#: 141538

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Product Information

  • Product Name
    Anti-CD44 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Mouse CD44
  • Tested applications
  • Species reactivity
    Mouse CD44
  • Alternative names
    AL133330.1 antibody; AU023126 antibody; AW121933 antibody; AW146109 antibody; Pgp1 antibody; CD44 antibody; Cd44 antibody; CDW44 antibody; CSPG8 antibody; ECMR-III antibody; HCELL antibody; HERMES antibody; HUTCH-I antibody; IN antibody; LHR antibody; Ly-24 antibody; MC56 antibody; MDU2 antibody; MDU3 antibody; MGC10468 antibody; MIC4 antibody; Pgp-1 antibody; RP23-203N8.3 antibody; IN antibody; LHR antibody; MC56 antibody; MDU2 antibody; MDU3 antibody; MIC4 antibody; Pgp1 antibody; CDW44 antibody; CSPG8 antibody; HCELL antibody; HUTCH-I antibody; ECMR-III antibody; Ly-24 antibody; Pgp-1 antibody; HERMES antibody; AU023126 antibody; AW121933 antibody; AW146109 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse CD44, and purified by antigen affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 0.1-2 μg/mL

  • Validations

    Mouse CD44 Immunohistochemistry(IHC) 15244

    Mouse CD44 Immunohistochemistry(IHC) 15244

  • Background
    CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.