Anti-C1 inhibitor/SerpinG1 antibody

Cat.#: 102493

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Product Information

  • Product Name
    Anti-C1 inhibitor/SerpinG1 antibody
  • Documents
  • Description
    Rabbit monoclonal to C1 inhibitor/SerpinG1
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human SerpinG1 / C1IN
    No cross-reactivity in ELISA with Human SerpinA1 / A1AT; Human SerpinA3 / SERPINA3 / AACT; Human SerpinA5 / PROCI; Human SerpinC1 /SERPINC1/ Antithrombin-III; Human SerpinD1 / SERPIND1 / HC2; Human SerpinF1 / SERPINF1 / PEDF; Human SerpinF2 / SERPINF2; Human SerpinI1 / SERPINI1 / Protease inhibitor 12
  • Alternative names
    C1 inhibitor antibody; C1 inhibitor antibody; C1IN antibody; C1INH antibody; C1INH antibody; C1NH antibody; C1nh antibody; HAE1 antibody; HAE2 antibody; RP23-399J8.3 antibody; Serping1 antibody; SERPING1 antibody; C1IN antibody; C1NH antibody; HAE1 antibody; HAE2 antibody; C1INH antibody; C1nh antibody; C1INH antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinG1 (rh SerpinG1; NP_000053.2; Met 1-Ala 500).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-10 μg/mL

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SERPING1. The detection limit for Human SERPING1 is approximately 0.00245 ng/well.

    IP: 0.5-2 μg/mg of lysate

  • Validations

    SerpinG1 / C1 inhibitor / C1IN Antibody, Rabbit MAb, Western blot

    SerpinG1 / C1 inhibitor / C1IN Antibody, Rabbit MAb, Western blot

    SerpinG1 / C1 inhibitor / C1IN Antibody, Rabbit MAb

    SerpinG1 / C1 inhibitor / C1IN Antibody, Rabbit MAb

  • Background
    Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.
  • References
    • Davis AE 3rd. et al. (2004) Biological effects of C1 inhibitor. Drug News Perspect. 17(7): 439-46.
    • Cicardi M, et al. (2005) C1 inhibitor: molecular and clinical aspects. Springer Semin Immunopathol. 27(3): 286-98.
    • Wouters D, et al. (2008) C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther. 8(8): 1225-40.
    • Cugno M, et al. (2009) C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 15(2): 69-78.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"