Anti-BIRC5 antibody

Cat.#: 142847

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Product Information

  • Product Name
    Anti-BIRC5 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human BIRC5
  • Tested applications
    WB, ELISA, ICC/IF, IF
  • Species reactivity
    Human Survivin / BIRC5 / API4
  • Alternative names
    baculoviral IAP repeat containing 5 antibody; BIRC5 antibody; API4 antibody; EPR-1 antibody; apoptosis inhibitor 4 antibody; apoptosis inhibitor survivin antibody; baculoviral IAP repeat-containing protein 5 antibody; survivin variant 3 alpha antibody; baculoviral IAP repeat-containing 5 antibody; Birc5 antibody; RP23-268N22.2 antibody; AAC-11 antibody; Api4 antibody; TIAP antibody; survivin40 antibody; apoptosis inhibitor 4 antibody; apoptosis inhibitor survivin antibody; baculoviral IAP repeat-containing protein 5 antibody; survivin antibody; IAP4 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human Survivin / BIRC5 / API4 . Survivin / BIRC5 / API4 specific IgG was purified by Human Survivin / BIRC5 / API4 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-20 μg/ml

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human Survivin / BIRC5 / API4.

    ICC/IF: 0.5-3 μg/mL

  • Validations

    Human Survivin/BIRC5/API4 Western blot (WB) 14692

    Human Survivin/BIRC5/API4 Western blot (WB) 14692

    Human Survivin/BIRC5/API4 Immunofluorescence(IF) 14693

    Human Survivin/BIRC5/API4 Immunofluorescence(IF) 14693

  • Background
    BIRC5, also known as Survivin and EPR-1, is a member of the IAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Survivin acts as an important regulator of the localization of this complex. It may counteract a default induction of apoptosis in G2/M phase.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"