Anti-Bcr Rabbit antibody

Cat.#: 168062

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Bcr Rabbit antibody
  • Documents
  • Description
    Bcr Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Bcr
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/2000

    IHC: 1/20

    ICC/IF: 1/50

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of Bcr in A549,HL-60,U2OS,C6 cell lysates using Bcr Rabbit mAb(1:1000 diluted).Predicted band size:143kDa.Observed band size:160kDa.

    Western blot detection of Bcr in A549,HL-60,U2OS,C6 cell lysates using Bcr Rabbit mAb(1:1000 diluted).Predicted band size:143kDa.Observed band size:160kDa.

  • Background
    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"