Anti-APOH antibody

Cat.#: 142326

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Product Information

  • Product Name
    Anti-APOH antibody
  • Documents
  • Description
    Rabbit Polyclonal to Rat APOH
  • Tested applications
    WB, ELISA
  • Species reactivity
    Rat Apolipoprotein H / APOH
  • Alternative names
    BG antibody; B2G1 antibody; B2GP1 antibody; B2GPI antibody; beta2-GPI antibody; beta-2-GPI antibody; APOH antibody; Apoh antibody; Apolipoprotein H antibody; Apolipoprotein H antibody; B2G1 antibody; B2GPI antibody; beta2-GPI antibody; beta-2-GPI antibody; BG antibody; RP23-261J24.1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Rat Apolipoprotein H / APOH . Apolipoprotein H / APOH specific IgG was purified by Rat Apolipoprotein H / APOH affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-20 μg/ml

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Rat Apolipoprotein H / APOH.

  • Validations

    Apolipoprotein H / APOH Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    Apolipoprotein H / APOH Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"