Anti-ACY1 antibody

Anti-ACY1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse ACY1

WB, ELISA, IHC-P, IP

Mouse Aminoacylase-1 / ACY1

1110014J22Rik antibody; Acy1 antibody; ACY1 antibody; ACY-1 antibody; Acy-1 antibody; ACY1D antibody; ACYLASE antibody; aminoacylase-1 antibody; ACY-1 antibody; ACY1D antibody; HEL-S-5 antibody; Acy-1 antibody; 1110014J22Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse Aminoacylase-1 / ACY1 . Aminoacylase-1 / ACY1 specific IgG was purified by Mouse Aminoacylase-1 / ACY1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.