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Anti-ACRV1 antibody

Cat.#: 103127

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Product Information

  • Product Name
    Anti-ACRV1 antibody
  • Documents
  • Description
    Rabbit polyclonal to ACRV1
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human ACRV1
  • Alternative names
    SP-10 antibody; ACRV1 antibody; Acrv1 antibody; D11S4365 antibody; Msa63 antibody; SP-10 antibody; SPACA2 antibody
  • Immunogen
    Human ACRV1 (His Tag) recombinant protein
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human ACRV1 (rh ACRV1; P26436-1, Gln 22-Ile 265). ACRV1 specific IgG was purified by Human ACRV1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ACRV1. The detection limit for Human ACRV1 is approximately 0.00245 ng/well.

    IHC-P: 0.05-1 μg/mL

  • Validations

    ACRV1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    ACRV1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human ACRV1 in human testis with rabbit polyclonal antibody (0.05 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Acrosomal protein SP-10, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. The longest transcript of ACRV1 / SP-10 is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. ACRV1 / SP-10 is a testis-specific acrosomal protein that has been detected in several species including humans. It may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. ACRV1 / SP-10 may be involved in sperm-zona binding or penetration. It is also a intra-acrosomal protein that is considered to be a vaccine candidate for immunocontraception.
  • References
    • Wright RM, et al.,1990, Biol Reprod. 42 (4): 693-701.
    • Kurth,B.E. et al., 1993, Anat Rec. 236 (4):619-25.
    • Golden WL, et al.,1994, Genomics.18 (2): 446-9. 
    • Foster,J.A. et al., 1994, Biol Reprod. 51 (6):1222-31.
    • Abhyankar,M.M. et al., 2007, J Biol Chem. 282 (50): 36143-54.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"