Anti-ABL1 antibody

Anti-ABL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human ABL1

ELISA, IHC-P, ICC/IF, IF

Human c-Abl / ABL1

ABL antibody; JTK7 antibody; p150 antibody; c-ABL antibody; v-abl antibody; c-ABL1 antibody; bcr/abl antibody; Abl antibody; c-Abl antibody; AI325092 antibody; E430008G22Rik antibody; ABL antibody; Abl antibody; ABL1 antibody; Abl1 antibody; AI325092 antibody; bcr/abl antibody; c-ABL antibody; c-Abl antibody; E430008G22Rik antibody; JTK7 antibody; MGC117749 antibody; p150 antibody; RP11-83J21.1 antibody; RP23-65P13.3 antibody; v-abl antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human c-Abl / ABL1 . c-Abl / ABL1 specific IgG was purified by Human c-Abl / ABL1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.

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