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Product Name
Recombinant ANR49 protein (His tag)
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Description
Recombinant ANKRD49 protein fragment (residues 1-239), derived from human Ankyrin repeat domain-containing protein 49, also known as Fetal globin-inducing factor. This high-quality fragment is designed for structural and functional studies, offering a stable and soluble unit ideal for investigating its role in globin gene regulation and cellular processes.
Ankyrin repeat domain-containing protein 49 (ANKRD49) is a human protein that functions as a fetal globin-inducing factor, specifically inducing expression of the HBG1 gene. It has been implicated in spermatogenesis, where it may promote autophagy in response to serum starvation via the NF-kappaB pathway. The protein is localized to the nucleus, consistent with its role in gene regulation. The recombinant fragment (residues 1-239) represents a computationally selected stable domain, enabling detailed biochemical and structural analysis of this important regulatory protein.
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Protein name
Ankyrin repeat domain-containing protein 49
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Uniprot ID
Q8WVL7
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Gene Name
ANKRD49; FGIF
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-239 aa (Q8WVL7) were fused with 6His tag.
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Sequence
1-239
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 28.95 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 33 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"