Allatostatin B 12 peptide

Allatostatin B 12 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-VPNDWAHFRGSW-NH2

H-Val-Pro-Asn-Asp-Trp-Ala-His-Phe-Arg-Gly-Ser-Trp-NH2

12

95.88%

C₆₉H₉₁N₂₁O₁₆

1470.59

Synthetic

Powder

The source of Allatostatin B 12 is common shore crab / green crab (Carcinus maenas).
Allatostatin B 12, which is also called CbAST-B1, is a novel B type allatostatin identified and sequenced in the pericardial organs of the crabs, Cancer borealis and Cancer productus. It shares a conserved C-terminal motif of W(X)6W, which is characteristic of the B-type allatostatin peptide family.
Allatostatin B 12 has been found to modulate the pyloric rhythm of the crab's stomatogastric ganglion (STG) in a dose-dependent manner. It reduces the pyloric network frequency and its effects depend on the preceding physiological state of the preparation.
Despite its dissimilarity in amino acid sequence with the A-type allatostatin family, Allatostatin B 12 has similar physiological effects to AST-A. The frequency of the pyloric rhythm is dependent on neuromodulatory inputs from the anterior ganglia, and the effects of Allatostatin B 12 on the pyloric neurons are dependent on the starting frequency of the pyloric rhythm.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Fu Q, Tang LS, Marder E, Li L. Mass spectrometric characterization and physiological actions of VPNDWAHFRGSWamide, a novel B type allatostatin in the crab, Cancer borealis. J Neurochem. 2007 May;101(4):1099-107.
• Ma M, Bors EK, Dickinson ES, et al. Characterization of the Carcinus maenas neuropeptidome by mass spectrometry and functional genomics. Gen Comp Endocrinol. 2009;161(3):320-34.
• Szabo TM, Chen R, Goeritz ML, Maloney RT, Tang LS, Li L, Marder E. Distribution and physiological effects of B-type allatostatins (myoinhibitory peptides, MIPs) in the stomatogastric nervous system of the crab Cancer borealis. J Comp Neurol. 2011 Sep 1;519(13):2658-76.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.