Recombinant ALK protein (His tag)

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Recombinant Human ALK Tyrosine Kinase Receptor Fragment (aa 143-635) - A high-purity protein fragment encompassing the MAM 1 and LDL-receptor class A domains, designed for studying receptor function and signaling mechanisms in neurological development and metabolic regulation.

ALK (Anaplastic Lymphoma Kinase) is a neuronal receptor tyrosine kinase (EC 2.7.10.1) transiently expressed in specific regions of the central and peripheral nervous systems, playing crucial roles in nervous system genesis and differentiation. This membrane-anchored protein (CD246) functions as a key regulator of energy expenditure and acts as a negative regulator of white adipose tissue lipolysis. Upon activation by ligands such as ALKAL2, ALK transduces extracellular signals into intracellular responses through phosphorylation of targets including CBL, FRS2, IRS1, and SHC1, activating the MAPK pathway and driving NF-kappa-B activation. The protein's membrane localization is essential for promoting neuron-like differentiation and regulating cell proliferation through specific MAP kinase pathway activation.