Recombinant ALDR protein (His tag)

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Recombinant Aldo-keto reductase family 1 member B1 (AKR1B1) fragment (residues 2-316) from Homo sapiens. This high-purity protein is a stable and soluble unit engineered for structural and biochemical studies, supporting research into its broad catalytic roles in carbonyl reduction, glucose metabolism, and detoxification pathways.

Aldo-keto reductase family 1 member B1 (AKR1B1), also known as Aldehyde reductase or Aldose reductase, is a cytoplasmic enzyme that catalyzes the NADPH-dependent reduction of diverse carbonyl-containing compounds to their corresponding alcohols. It acts on endogenous metabolites, including aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids, steroids, prostaglandins, and xenobiotics. A key player in the polyol pathway, AKR1B1 reduces glucose to sorbitol under hyperglycemic conditions. It also detoxifies dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde and 4-hydroxynonenal, and reduces phospholipid aldehydes generated from oxidized phospholipids. The enzyme displays activity toward retinoids and glutathione-conjugated carbonyls, highlighting its role in cellular protection and metabolic regulation.