AES16-2M peptide
Not For Human Use, Lab Use Only.
Cat.#: 319170
Special Price 94.2 USD
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Product Name
AES16-2M peptide
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Sequence Shortening
H-REGRT-OH
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Sequence
H-Arg-Glu-Gly-Arg-Thr-OH
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Length (aa)
5
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Peptide Purity (HPLC)
95.99%
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Molecular Formula
C23H43N11O9
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Molecular Weight
617.65
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Source
Synthetic
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Form
Powder
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Description
AES16-2M peptide is a small wound healing peptide with a sequence of REGRT. AES16-2M was shown to induce ERK activation in keratinocytes and enhanced wound repair which is comparable to the respective effects of TGFβ and EGF. AES16-2M significantly reduced the dermatitis score, ear thickness, and the level of blood IgE and TSLP in AD mice. AES16-2M could be a novel candidate for AD(atopic dermatitis) treatment.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Kim MS, Song J, Park S, Kim TS, Park HJ, Cho D. The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo. Molecules. 2021 Feb 22;26(4):1168.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"