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Product Name
Recombinant ADR1 protein (His tag)
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Description
Discover our high-quality recombinant protein fragment of A-to-I RNA editing regulator adr-1 (residues 173-247) from Caenorhabditis elegans. This 75-amino acid fragment contains the complete DRBM 1 domain, providing researchers with a specialized tool for studying RNA binding mechanisms and regulatory functions in A-to-I RNA editing processes.
The full-length A-to-I RNA editing regulator adr-1 from Caenorhabditis elegans is essential for the hydrolytic deamination of adenosine to inosine in double-stranded RNA. While lacking deaminase activity itself, adr-1 binds to dsRNA and regulates A-to-I RNA editing by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 to target adenosines. This protein plays critical roles in regulating editing efficiency in 3' untranslated regions of specific mRNAs, neuronal function, chemotaxis, vulva development, and lifespan determination. Adr-1 is localized in both the nucleus and cytoplasm, detected in nuclear fractions and ribosome-containing cytoplasmic pellets, reflecting its diverse functional roles in RNA processing and cellular regulation.
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Protein name
A-to-I RNA editing regulator adr-1
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Uniprot ID
Q9U3D6
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Gene Name
adr-1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 173-247 aa (Q9U3D6) were fused with 6His tag.
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Sequence
173-247
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 10.19 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 10 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"