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Product Name
Discontinued, ADA19 protein (His tag)
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Description
Recombinant Human ADAM19 Fragment (aa 209-699) is a high-purity protein designed for studying the functional domains of Disintegrin and metalloproteinase domain-containing protein 19. This fragment includes the Peptidase M12B, Disintegrin, and EGF-like domains, making it an ideal tool for investigating neurogenesis, synaptogenesis, and proteolytic mechanisms in glial and osteoblast systems.
ADAM19, also known as Meltrin-beta, is a membrane-anchored metalloproteinase involved in key biological processes. It participates in the proteolytic processing of beta-type neuregulin isoforms, which are critical for neurogenesis and synaptogenesis, indicating a regulatory role in glial cell function. Additionally, ADAM19 cleaves alpha-2 macroglobulin and may contribute to osteoblast differentiation and activity in bone development. As a single-pass type I membrane protein, it is localized to the cell membrane, facilitating its interactions in extracellular signaling pathways. The provided fragment (aa 209-699) encompasses essential functional domains, enabling focused research on its enzymatic and disintegrin activities without the full transmembrane region.
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Protein name
Disintegrin and metalloproteinase domain-containing protein 19
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Uniprot ID
Q9H013
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Gene Name
ADAM19; MLTNB
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 209-699 aa (Q9H013) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 55.52 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 56 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"