Acetyl Tetrapeptide-3

Acetyl Tetrapeptide-3

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Ac-KGHK-NH2

Ac-Lys-Gly-His-Lys-NH2

4

97.94%

C₂₂H₃₉N₉O₅

509.6

Synthetic

Powder

Acetyl tetrapeptide-3 is a biomimetic peptide derived from a growth factor, also known by the trading name Folixyl®. It has a sequence Ac-Lys-Gly-His-Lys-NH2 (KGHK) specially designed to fight the symptoms of hair loss and stimulate hair growth. With its ability to stimulate the synthesis of follicle extracellular matrix proteins (Collagen I and III, laminin), Acetyl tetrapeptide-3 helps the renewal of dermal papilla cells and opposes the stiffening of the sheath of the hair follicle that causes hair loss. Tests on human hair follicles showed that Acetyl tetrapeptide-3 stimulates hair growth. Compared with Minoxidil, a reference in hair growth treatment, Folixyl® was superior in regards to the percentage of hair growth after 7 days of treatment.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Lueangarun S, Panchaprateep R. An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial. J Clin Aesthet Dermatol. 2020 Oct;13(10):32-37. Epub 2020 Oct 1.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.