Recombinant ABL1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Tyrosine-protein kinase abl-1 (EC 2.7.10.2) fragment (residues 118-585) from Caenorhabditis elegans. This 468-amino acid construct encompasses the complete SH2 and Protein kinase domains, providing an essential tool for studying domain-specific functions in neuroblast migration and stress-induced apoptosis signaling pathways.

Tyrosine-protein kinase abl-1 functions downstream of migratory protein mig-13 and plays a critical role in Q neuroblast migration during larval development. The protein is recruited by mig-13 to the leading edge of Q neuroblasts and their descendants, where it signals downstream, likely through the wve-1 pathway, to direct migration along the anteroposterior body axis. Additionally, abl-1 promotes germline cell apoptosis in response to oxidative, osmotic, and heat shock stresses. The protein localizes to both the cell membrane and cytoplasm, with enrichment observed at the leading edge of migrating neuroblasts compared to the cytoplasm, where it is targeted by mig-13 for proper cellular positioning and function.