Recombinant ABHD6 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Monoacylglycerol Lipase ABHD6 (EC 3.1.1.23) Fragment (aa 30-337) is a high-purity protein designed for studying endocannabinoid signaling and lysosomal lipid metabolism. This 308-amino acid fragment fully encompasses the functional AB hydrolase-1 domain, making it an ideal tool for enzymatic assays, inhibitor screening, and functional domain analysis.

Monoacylglycerol lipase ABHD6 is a key enzyme in lipid metabolism that preferentially hydrolyzes medium-chain saturated monoacylglycerols, including the endocannabinoid 2-arachidonoylglycerol, thereby regulating endocannabinoid signaling pathways. The enzyme also exhibits lysophosphatidyl lipase activity with preference for lysophosphatidylglycerol and serves as the major catabolic enzyme for bis(monoacylglycero)phosphate (BMP), which plays a crucial role in late endosome/lysosome function and lipid sorting. ABHD6 localizes to multiple cellular membranes including late endosomes, lysosomes, and mitochondria as a single-pass type II membrane protein, highlighting its importance in intracellular lipid homeostasis and membrane biology.