Recombinant A16L1 protein (His tag)

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Recombinant Human Autophagy-related protein 16-1 (ATG16L1) Fragment (aa 307-607) - A high-quality protein fragment designed for structural and biochemical studies of autophagy regulation. This 301-amino acid fragment represents a stable, soluble region ideal for investigating the molecular mechanisms of canonical and non-canonical autophagy pathways.

Autophagy-related protein 16-1 (ATG16L1) serves as a critical molecular hub coordinating both canonical and non-canonical autophagy pathways. The full-length protein interacts with ATG12-ATG5 to mediate lipidation of ATG8 family proteins, controlling autophagosomal membrane elongation during canonical autophagy. Additionally, it participates in non-canonical autophagy by catalyzing conjugation of ATG8 proteins to single membranes at endolysosomal compartments. ATG16L1 regulates mitochondrial antiviral signaling-dependent type I interferon production and modulates NOD1- and NOD2-driven inflammatory responses while promoting autophagy-dependent antibacterial pathways. The protein localizes to multiple cellular compartments including cytoplasm, preautophagosomal structure membranes, endosomes, and lysosomes, functioning as a peripheral membrane protein that translocates to phagophores under starved conditions.

307-607