![[Leu15]-Gastrin I (human) peptide](/uploads/peptides/catalog_peptide.webp)
[Leu15]-Gastrin I (human) peptide
Not For Human Use, Lab Use Only.
Cat.#: 319828
Special Price 165.10 USD
Availability:
1-2 weeks
-
Product Name
[Leu15]-Gastrin I (human) peptide
-
Documents
Batch to batch variation of the purity
-
Sequence Shortening
Pyr-GPWLEEEEEAYGWLDF-NH2
-
Sequence
Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
-
Length (aa)
16
-
Peptide Purity (HPLC)
95.42%
-
Molecular Formula
C98H126N20O31
-
Molecular Weight
2080.15
-
CAS No.
39024-57-2
-
Source
Synthetic
-
Form
Powder
-
Description
[Leu15]-Gastrin I (human) is a peptide hormone primarily synthesized in the G cells of the stomach antrum. It plays a crucial role in stimulating gastric acid secretion from parietal cells via activation of the cholecystokinin-B (CCK-B) receptor, a G-protein-coupled receptor. This peptide also exhibits trophic effects on the gastrointestinal epithelium, influencing growth and maintenance of the digestive tract. In addition to its physiological functions, [Leu15]-Gastrin I (human) and its receptors are found to be overexpressed in certain malignancies, where it may contribute to cellular proliferation through autocrine signaling pathways.
The molecular actions of [Leu15]-Gastrin I (human) are mediated through the CCK-B receptor, triggering downstream signaling cascades involving phospholipase C, protein kinase C, and calcium mobilization. Beyond its role in acid regulation, this peptide has been implicated in activating pathways such as the Ras-ERK and EGFR transactivation, which are critical for cell proliferation and survival. Its expression is not limited to endocrine cells, as it is also detected in epithelial tumors, suggesting a potential role in neoplastic growth mechanisms.
-
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
-
References
- Smith JP, Nadella S, Osborne N. Gastrin and Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar 14;4(1):75-83. doi: 10.1016/j.jcmgh.2017.03.004. PMID: 28560291; PMCID: PMC5439238.
-
About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
-
Molar Concentration Calculator
-
Dilution Calculator
-
Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"