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Dissociation constant pKa (25 °C), dpKa/dT, and molecular mass of buffers

SubstancepKadpKa/dTMr
Oxalate (oxalic acid) (pK1)1.27
90.0
Maleate (maleic acid) (pK1)2.000116.1
Phosphate (phosphoric acid) (pK1)2.150.004498.0
Glycine (pK1)2.35−0.00275.1
Phthalate (phthalic acid) (pK1)2.950.0020166.1
Glycylglycine (pK1)3.12
132.1
Malate (malic acid) (pK1)3.40
134.1
Formiate (formic acid)3.75046.0
Barbituric acid (pK1)4.04
128.1
Succinate (succinic acid) (pK1)4.21−0.0018118.1
Oxalate (oxalic acid) (pK2)4.27
90.0
Acetate (acetic acid)4.750.000260.0
Citrate (citric acid) (pK2)4.76−0.0016192.1
Malate (malic acid) (pK2)5.13
134.1
Pyridine5.23−0.01479.1
Phthalate (phthalic acid) (pK2)5.41
166.1
Piperazine (pK2)5.55−0.01586.1
Succinate (succinic acid) (pK2)5.640118.1
Malonate (malonic acid) (pK2)5.70
104.1
Histidine (pK2)5.97−0.017155.2
Maleate (maleic acid) (pK2)6.07
116.1
MES (2-morpholinoethanesulfonic acid)6.10−0.011195.2
Cacodylate (cacodylic acid. dimethy-larsinic acid)6.27
138.0
Carbonate (carbonic acid) (pK1)6.35−0.005562.0
Citrate (citric acid) (pK3)6.400192.1
BIS-Tris (bis(2-hydroxyethyl) imino-tris(hydroxymethyl)-methane)6.46−0.02209.5
ADA (N-carbamoylmethyl-iminodiacetic acid)6.59−0.011190.2
PIPES (1.4-piperazine-bis-ethane sulfonic acid)6.76−0.0085302.4
ACES (N-(2-acetamido)-2- aminoethanesulfonic acid)6.78−0.02182.2
BIS-Tris Propane (1.3-bis[tris(hydroxy- methyl)- methylamino]-propane) (pK1)6.80−0.028282.3
Imidazole6.95−0.0268.1
MOPSO (3-(N-morpholino)-2-hydroxypopanesulfonic acid)6.95−0.015225.3
BES (2-[bis(2-hydroxyethyl)-amino]- ethansulfonsäure)7.09−0.016213.3
Phosphate (phosphoric acid) (pK2)7.21−0.002898
MOPS (4-morpholino-propane sulfonic7.31−0.011209.3
TES (2-[tris(hydroxymethyl)-methyl-amino]-1-ethanesulfonic acid)7.40−0.02229.5
HEPES (4-(2-hydroxyethyl)-1-piperazine-ethanesulfonic acid)7.48−0.014238.3
DIPSO (3-[bis(2-hydroxyethyl)amino]-2- hydroxypropane-1-sulfonic acid)7.60−0.02243.3
Triethanolamine (TEA)7.76−0.02149.2
POPSO (piperazine-N.Nt-bis(2-hydroxypropanesulfonic acid))7.85−0.013362.4
Barbital (diethylbarbituric acid, Veronal)7.98
184.2
HEPPS (EPPS. 4-(2-hydroxyethyl)-1-piperazin-propanesulfonic acid)8.00
252.3
Tricine (N-[tris(hydroxymethyl)-methyl]-glycine)8.05−0.021179.2
Glycinamide hydrochloride8.06−0.029110.5
Tris (tris(hydroxymethyl)-amino methan; 2-amino-2-hydroxy methyl-propane-1.3-diol; Trizma)8.06−0.028121.1
PIPPS (1.4-bis(3-sulfopropyl)-piperazine)8.10
330.4
Glycylglycine (pK2)8.25−0.025132.1
Bicine (N.N-bis(2-hydroxyethyl)-glycine)8.26−0.018163.2
TAPS (3-tris(hydroxymethyl)-methylamino)-1-propanesulfonic acid8.400.018243.3
AMPSO (3-([1.1-dimethyl- 2-hydoxyethyl]amino)-2-hydroxypropane sulfonic acid)8.40
227.3
Diethanolamine8.88
105.1
Histidine (pK3)8.97
155.2
BIS-Tris propane (1.3-bis[tris (hydroxymethyl)-methylamino] propane) (pK2)9.00−0.028282.3
AES (2-aminoethylsulfonic acid; taurine)9.06−0.022125.2
Borate (boric acid. H3BO3)9.23−0.00861.8
Ammonia9.25−0.03117
Ethanolamine9.50−0.02961.1
CHES (2-cyclohexylaminoethanesulfonic acid)9.55−0.018207.3
CAPSO (3-cyclohexylamino-2- hydroxypropanesulfonic acid)9.71−0.018237.3
Glycine (pK2)9.78−0.02575.1
EDPS (N.Nt-bis(3-sulfopropyl)-ethylenediamine)9.80

Carbonate (carbonic acid) (pK2)10.33−0.00962
CAPS (3-(cyclohexylamino)-1-propanesulfonic acid)10.400.032221.3
Ethylamine10.62
45.1
Triethylamine10.72
101.2
Piperidine11.12−0.03185.2
Phosphate (phosphoric acid) (pK3)12.33−0.02698.0

Souce: NovoPro    2019-07-02