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Recombinant YETS4 protein (His tag)

Cat.#: 541931

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Product Information

  • Product Name
    Recombinant YETS4 protein (His tag)
  • Documents
  • Description

    Recombinant YEATS4 (YEATS domain-containing protein 4) fragment encompassing the complete YEATS domain (amino acids 1-227). This high-purity recombinant protein serves as an essential tool for studying chromatin recognition mechanisms, specifically investigating the YEATS domain's role in binding acylated histone H3 modifications and its function within the NuA4 histone acetyltransferase complex.

    YEATS4 (also known as Gas41 or NuBI-1) is a crucial chromatin reader component of the NuA4 histone acetyltransferase complex, which plays a fundamental role in transcriptional activation through acetylation of nucleosomal histones H4 and H2A. The protein specifically recognizes and binds acylated histone H3, demonstrating preferential binding to histone H3 diacetylated at Lys-18 and Lys-27 (H3K18ac and H3K27ac) or Lys-14 and Lys-27 (H3K14ac and H3K27ac), and also recognizes crotonylated histone H3. YEATS4 is localized to the nucleus and plays a key role in histone variant H2AZ1/H2A.Z deposition into specific

  • Protein name
    YEATS domain-containing protein 4
  • Uniprot ID
    O95619
  • Gene Name
    YEATS4; GAS41
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-227 aa (O95619) were fused with N-terminal 6His tag.
  • Sequence 
    MNHKVHHHHH HGGSMFKRMA EFGPDSGGRV KGVTIVKPIV YGNVARYFGK KREEDGHTHQ WTVYVKPYRN EDMSAYVKKI
QFKLHESYGN PLRVVTKPPY EITETGWGEF EIIIKIFFID PNERPVTLYH LLKLFQSDTN AMLGKKTVVS EFYDEMIFQD
PTAMMQQLLT TSRQLTLGAY KHETEFAELE VKTREKLEAA KKKTSFEIAE LKERLKASRE TINCLKNEIR KLEEDDQAKD
I
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 28.12 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 30 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant YETS4 protein (His tag) SDS-PAGE

    Recombinant YETS4 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: YETS4; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"