Recombinant TBXT protein (His tag)

• DataSheet
• COA (Batch NP456515)
• Material Safety Data Sheets (MSDS)

This product is a recombinant fragment of the human T-box transcription factor T (Brachyury protein), encompassing amino acids 40-223. This 184-residue fragment is engineered for stability and solubility, making it an ideal tool for structural studies and biochemical assays focused on mesoderm formation and transcriptional regulation.

The full-length Brachyury protein, encoded by the TBXT gene, is a key transcription factor involved in mesoderm formation and differentiation. It functions by binding to the palindromic T-site DNA sequence (5'-TTCACACCTAGGTGTGAA-3') to activate transcription of genes critical for embryonic development. The protein is localized to the nucleus, where it exerts its regulatory role. This fragment was selected computationally to provide a stable, soluble unit that retains utility for investigating the protein's functional mechanisms without containing known domains, facilitating research into its structural and interaction properties.

MSKIKRELRV GLEESELWLR FKELTNEMIV TKNGRRMFPV LKVNVSGLDP NAMYSFLLDF VAADNHRWKY VNGEWVPGGK
PEPQAPSCVY IHPDSPNFGA HWMKAPVSFS KVKLTNKLNG GGQIMLNSLH KYEPRIHIVR VGGPQRMITS HCFPETQFIA
VTAYQNEEIT ALKIKYNPFA KAFLDAKERL EHHHHHH