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Product Name
Recombinant STAP2 protein (His tag)
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Description
Recombinant Human Signal-transducing Adaptor Protein 2 (STAP-2) Fragment (residues 1-247) is a high-purity protein designed for studying the pleckstrin homology (PH) domain and its regulatory roles in inflammation and STAT3 signaling pathways. This fragment serves as an essential tool for kinase assays, protein interaction studies, and functional investigations.
Signal-transducing Adaptor Protein 2 (STAP-2), also known as Breast Tumor Kinase (BRK) substrate, is a cytoplasmic protein involved in modulating the acute-phase response during systemic inflammation. It functions as a substrate for protein kinase PTK6 and plays a regulatory role in STAT3 activity, contributing to inflammatory signaling mechanisms. The full-length protein is localized in the cytoplasm, where it mediates key signal transduction events relevant to immune responses and cellular regulation.
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Protein name
Signal-transducing adaptor protein 2
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Uniprot ID
Q9UGK3
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Gene Name
STAP2; BKS
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-247 aa (Q9UGK3) were fused with C-terminal 6His tag.
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Sequence
MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF YNSNRDFQHV EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV ETLECREMWK GFILTVVELR VPTDLTLLPG HLYMMSEVLA KEEARRALET PSCFLKVSRL EAQLLLERYP ECGNLLLRPS GDGADGVSVT TRQMHNGTHV VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA LVPFLLDLEH HHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 29.37 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 30 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant STAP2 protein (His tag) SDS-PAGE
M: Marker; Lane 1: STAP2; Lane 2: BSA
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