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Recombinant SC65 protein (His tag)

Cat.#: 547873

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Product Information

  • Product Name
    Recombinant SC65 protein (His tag)
  • Documents
  • Description

    Recombinant human Endoplasmic reticulum protein SC65 (P3H4) fragment (residues 19-378) is a high-quality protein product designed for structural and biochemical studies. This 360-amino acid fragment represents a stable and soluble unit, ideal for investigating collagen hydroxylation and fibril assembly mechanisms.

    The full-length Endoplasmic reticulum protein SC65 (P3H4) is a critical component of a complex with PLOD1 and P3H3 that catalyzes lysine hydroxylation in collagen alpha chains. This enzymatic activity is essential for proper collagen fibril assembly, cross-linking, and overall extracellular matrix integrity. The protein's function directly contributes to normal bone density and skin stability. As an endoplasmic reticulum-resident protein, it operates within the cellular compartment responsible for protein folding and post-translational modifications, positioning it centrally in collagen biosynthesis pathways.

  • Protein name
    Endoplasmic reticulum protein SC65
  • Uniprot ID
    Q92791
  • Gene Name
    P3H4; LEPREL4; NOL55; SC65
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 19-378 aa (Q92791) were fused with N-terminal 6His tag.
  • Sequence 
    MSKIKHHHHH HGGSQYEKYS FRGFPPEDLM PLAAAYGHAL EQYEGESWRE SARYLEAALR LHRLLRDSEA FCHANCSGPA
PAAKPDPDGG RADEWACELR LFGRVLERAA CLRRCKRTLP AFQVPYPPRQ LLRDFQSRLP YQYLHYALFK ANRLEKAVAA
AYTFLQRNPK HELTAKYLNY YQGMLDVADE SLTDLEAQPY EAVFLRAVKL YNSGDFRSST EDMERALSEY LAVFARCLAG
CEGAHEQVDF KDFYPAIADL FAESLQCKVD CEANLTPNVG GYFVDKFVAT MYHYLQFAYY KLNDVRQAAR SAASYMLFDP
KDSVMQQNLV YYRFHRARWG LEEEDFQPRE EAMLYHNQTA ELRELLEFTH MYLQ
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 43.47 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 46 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant SC65 protein (His tag) SDS-PAGE

    Recombinant SC65 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: SC65; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"