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  • Rat PD-L1/B7-H1/CD274 (Fc Tag) recombinant protein

Rat PD-L1/B7-H1/CD274 (Fc Tag) recombinant protein

Cat.#: 500983

Special Price 342.0 USD

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Product Information

  • Product Name
    Rat PD-L1/B7-H1/CD274 (Fc Tag) recombinant protein
  • Documents
  • Description
    Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
  • Protein name
    Protein Cd274
  • Uniprot ID
    D4AE25
  • Gene Name
    Cd274; RGD1566211_predicted; rCG_48457
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat CD274 (NP_001178883.1)(Met1-Thr238) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat CD274/Fc is a disulfide-linked homodimer. The reduced monomer comprises 459 amino acids and has a predicted molecular mass of 51.8 kDa. The apparent molecular mass of the protein is approximately 73.2 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized rat CD274-Fc at 10 μg/ml (100 μl/well) can bind biotinylated rat PDCD1-Fc (Cat:501471), The EC50 of biotinylated rat PDCD1-Fc (Cat:501471) is 0.14-0.34 μg/ml.
  • Validations

    Rat PD-L1 / B7-H1 / CD274 Protein (Fc Tag) SDS-PAGE

    Rat PD-L1 / B7-H1 / CD274 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"