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  • Human PD-L1/B7-H1/CD274 (His Tag) recombinant protein

Human PD-L1/B7-H1/CD274 (His Tag) recombinant protein

Cat.#: 503918

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Product Information

  • Product Name
    Human PD-L1/B7-H1/CD274 (His Tag) recombinant protein
  • Documents
  • Description
    Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
  • Protein name
    Programmed cell death 1 ligand 1
  • Protein short names
    MGC142296; B7-H; CD274 A530045L16RIK; MGC142294; PDL1; PDCD1LG1; PD-L1; CD274; B7H1; PDCD1L1
  • Uniprot ID
    Q9NZQ7
  • Gene Name
    CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal segment (Met 1-Thr 239) of the extracellular domain of human B7-H1 (NP_054862.1) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant mature human B7-H1 comprises 232 amino acids and predicts a molecular mass of 26.8 kDa. As a result of glycosylation, the rh B7-H1 migrates as an approximately 35-38 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human B7-H1 at 20 μg/ml (100 μl/well) can bind human PD1 with a linear ranger of 0.032-0.8 μg/ml.
  • Validations

    Human PD-L1 / B7-H1 / CD274 Protein (His Tag) SDS-PAGE

    Human PD-L1 / B7-H1 / CD274 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"