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Product Name
Recombinant MSMP protein (His tag)
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Description
Recombinant Human Prostate-associated microseminoprotein (PC3-secreted microprotein) Fragment (aa 36-139) is a high-purity, soluble protein designed for chemokine receptor research. This 104-amino acid fragment retains key functional regions, enabling studies on CCR2-mediated signaling, chemotaxis, and immune cell recruitment.
The full-length Prostate-associated microseminoprotein (MSMP) is a secreted human protein that functions as a ligand for the C-C chemokine receptor CCR2. Upon binding, it activates CCR2 to induce robust chemotactic responses and mobilize intracellular calcium ions. It demonstrates specific chemotactic activity for monocytes and lymphocytes but not neutrophils, highlighting its role in immune cell recruitment and inflammatory processes. As a secreted protein, it operates in extracellular environments, making it relevant for studying paracrine signaling in prostate biology and immune regulation.
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Protein name
Prostate-associated microseminoprotein
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Uniprot ID
Q1L6U9
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Gene Name
MSMP; PSMP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 36-139 aa (Q1L6U9) were fused with C-terminal 6His tag.
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Sequence
MSKIKSKCYF QAQAPCHYEG KYFTLGESWL RKDCFHCTCL HPVGVGCCDT SQHPIDFPAG CEVRQEAGTC QFSLVQKSDP RLPCKGGGPD PEWGSANTPV PGAPAPHSSL EHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 12.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant MSMP protein (His tag) SDS-PAGE
M: Marker; Lane 1: MSMP; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"