Recombinant IF2B2 protein (His tag)

• DataSheet
• COA (Batch NP456620)
• Material Safety Data Sheets (MSDS)

Recombinant Human IGF2BP2 Fragment (427-599) is a high-purity protein designed for studying the KH 3 and KH 4 domains of Insulin-like growth factor 2 mRNA-binding protein 2. This fragment serves as an essential tool for investigating RNA-binding mechanisms, mRNA stability regulation, and m6A-dependent transcript interactions in cellular models.

IGF2BP2 (IMP-2) is an RNA-binding protein that recruits target mRNAs to cytoplasmic messenger ribonucleoprotein (mRNP) complexes, facilitating transcript transport, storage, and protection from degradation. It preferentially stabilizes N6-methyladenosine (m6A)-modified mRNAs, including MYC and IGF2 transcripts, by binding to specific regions such as the coding region instability determinant. The protein localizes to the nucleus, cytoplasm, P-bodies, and stress granules, dynamically responding to cellular stress. Its role in mRNA 'caging' and stabilization makes it critical for understanding post-transcriptional gene regulation, cancer biology, and cellular stress responses.

MNHKVQEIVN LFIPTQAVGA IIGKKGAHIK QLARFAGASI KIAPAEGPDV SERMVIITGP PEAQFKAQGR IFGKLKEENF
FNPKEEVKLE AHIRVPSSTA GRVIGKGGKT VNELQNLTSA EVIVPRDQTP DENEEVIVRI IGHFFASQTA QRKIREIVQQ
VKQQEQKYPQ GVASQRSKLE HHHHHH